Modeling ligand docking to RNA in the design of RNA-based nanostructures.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2019.10.010
Abstract: RNA has grown in biological importance as the discovery of its many functional roles in the cellular machinery has revealed the potential for targeting it to disrupt cancer pathways. RNA structure underlies its functionality and… read more here.
Keywords: design rna; based nanostructures; rna; rna based ... See more keywords
Gold nanoparticle design for RNA compaction.
Sign Up to like & getrecommendations! Published in 2022 at "Biointerphases"
DOI: 10.1116/6.0002043
Abstract: RNA-based therapeutics hold a great promise in treating a variety of diseases. However, double-stranded RNAs (dsRNAs) are inherently unstable, highly charged, and stiff macromolecules that require a delivery vehicle. Cationic ligand functionalized gold nanoparticles (AuNPs)… read more here.
Keywords: nanoparticle design; rna; design rna; major groove ... See more keywords