Design, in silico studies, synthesis and in vitro evaluation of oseltamivir derivatives as inhibitors of neuraminidase from influenza A virus H1N1.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.039
Abstract: Since the neuraminidase (NA) enzyme of the influenza A virus plays a key role in the process of release of new viral particles from a host cell, it is often a target for new drug… read more here.
Keywords: h1n1; oseltamivir derivatives; design silico; influenza virus ... See more keywords
Statistical design of in silico experiments for the robustness analysis of electrophysiologic response simulators
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Pharmacological and Toxicological Methods"
DOI: 10.1016/j.vascn.2018.01.469
Abstract: To assess the risk of Torsade de Pointes, the CiPA initiative has proposed to test in silico models able to reconstruct electrophysiologic responses and analyze mechanistic causes of specific toxicological events such as TdP. One… read more here.
Keywords: statistical design; response; analysis; silico ... See more keywords
DESIGN AND IN SILICO EVALUATION OF PHENOXY ACETAMIDE DERIVATIVES AS POTENTIAL ANTIDIABETIC AGENTS
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2025v17i5.54892
Abstract: Objective: This study explores the interactions of phenoxy acetamide derivatives with AMP-activated protein kinase (AMPK), a key enzyme in metabolic regulation. The goal is to evaluate the AMPK activation potential of these compounds using in… read more here.
Keywords: evaluation phenoxy; acetamide derivatives; design silico; phenoxy acetamide ... See more keywords