Recent development in the design of small 'drug-like' and nanoscale glycomimetics against Escherichia coli infections.
Sign Up to like & getrecommendations! Published in 2021 at "Drug discovery today"
DOI: 10.1016/j.drudis.2021.02.025
Abstract: Glycoconjugates are involved in several pathological processes. Glycomimetics that can favorably emulate complex carbohydrate structures, while competing with natural ligands as inhibitors, are gaining considerable attention owing to their improved hydrolytic stability, binding affinity, and… read more here.
Keywords: escherichia coli; design small; drug; recent development ... See more keywords
Design of a Small Organic Template for the Synthesis of Self-Pillared Pentasil Zeolite Nanosheets.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c12338
Abstract: Zeolite nanosheets with excellent mass transfer are attractive, but their successful syntheses are normally resulted from a huge number of experiments. Here, we show the design of a small organic template for the synthesis of… read more here.
Keywords: small organic; zeolite; design small; zeolite nanosheets ... See more keywords
De novo design of small beta barrel proteins
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207974120
Abstract: Significance De novo design of mini-proteins for engineering new functions has primarily focused on all-alpha and alpha-beta folds. Despite the enormous functional diversity observed in naturally occurring beta barrels less than 70 residues in length,… read more here.
Keywords: small beta; beta barrel; novo design; design small ... See more keywords
How can we improve the design of small molecules to target thioredoxin reductase for treating cancer?
Sign Up to like & getrecommendations! Published in 2020 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2021.1854220
Abstract: The ubiquitous thioredoxin reductase (TrxR, encoded by TXNRD gene) enzymes are essential to maintain the cellular redox homeostasis. The most outstanding function of TrxR is to keep its native subs... read more here.
Keywords: thioredoxin reductase; improve design; reductase; design small ... See more keywords
Design of Small LNG Supply Chain by Multi-Period Optimization
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DOI: 10.3390/en13246704
Abstract: A mathematical model for the design of small-scale supply chains for liquefied natural gas (LNG) has been developed. It considers the maritime delivery of LNG from supply ports to satellite terminals and land-based transports from… read more here.
Keywords: multi period; supply; design small; supply chain ... See more keywords