Design and Synthesis of Comb‐Like Bisulfonic Acid Proton Exchange Membrane with Regulated Microstructure
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DOI: 10.1002/adfm.202316506
Abstract: The design and synthesis of proton exchange membranes (PEMs) with controllable microstructure and sulfonation degree play a crucial role in enhancing their performance and expanding their application. In this study, the disulfonic acid monomer is… read more here.
Keywords: design synthesis; microstructure; proton exchange; design ... See more keywords
Design, Synthesis, and Application of Immobilized Enzymes on Artificial Porous Materials
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DOI: 10.1002/advs.202500345
Abstract: Enzymes have been recognized as highly efficient biocatalysts, whereas characteristics such as poor stability and single reaction type greatly significantly limit their wide application. Hence, the exploitation of suitable carriers for immobilized enzymes enables the… read more here.
Keywords: porous materials; organic frameworks; artificial porous; design synthesis ... See more keywords
Design, Synthesis and Optical Properties of 2‐(1‐Azaazulenyl)pyrrole‐Boron Difluoride Complexes
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DOI: 10.1002/ajoc.202400804
Abstract: Herein, 1‐azaazulene‐based BF2 complexes with pyrrole as the amido N‐donor were synthesized via Suzuki‐Miyaura cross coupling of 2‐bromo‐1‐azaazulene and 1‐Boc‐2‐pyrroleboronic acid. The structures, especially the unique N–B linkages, were discussed based on the single crystal… read more here.
Keywords: properties azaazulenyl; azaazulenyl pyrrole; synthesis optical; pyrrole boron ... See more keywords
Design and Synthesis of 5‐Substituted Benzo[d][1,3]dioxole Derivatives as Potent Anticonvulsant Agents
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DOI: 10.1002/ardp.201600274
Abstract: A series of 5‐substituted benzo[d][1,3]dioxole derivatives was designed, synthesized, and tested for anticonvulsant activity using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens. Neurotoxicity was determined by rotarod test. In the preliminary screening, six… read more here.
Keywords: design synthesis; derivatives potent; synthesis substituted; dioxole derivatives ... See more keywords
Design, Synthesis, and Screening of Triazolopyrimidine–Pyrazole Hybrids as Potent Apoptotic Inducers
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DOI: 10.1002/ardp.201700137
Abstract: An efficient synthesis of novel 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐5,7‐dimethyl‐[1,2,4]triazolo[4,3‐a]‐pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives bearing the pyrazole scaffold were screened to evaluate them as a reproductive toxicant in… read more here.
Keywords: design synthesis; screening triazolopyrimidine; testicular germ; germ cells ... See more keywords
Design, synthesis, in silico and antiproliferative evaluation of novel pyrazole derivatives as VEGFR‐2 inhibitors
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DOI: 10.1002/ardp.201700234
Abstract: As the blockade of the VEGFR‐2 signaling pathway is a viable approach in cancer therapy, the present study focuses on a series of pyrazole based VEGFR‐2 inhibitors that were designed on the basis of the… read more here.
Keywords: design synthesis; evaluation novel; synthesis silico; vegfr inhibitors ... See more keywords
Design, synthesis, biological evaluations, molecular docking, and in vivo studies of novel phthalimide analogs
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DOI: 10.1002/ardp.201700363
Abstract: A series of novel phthalimide analogs containing an indole or brominated indole moiety were synthesized and their antimicrobial activity was evaluated. Compound 8 showed a broad spectrum activity, revealing 53–67% of erythromycin activity on the… read more here.
Keywords: design synthesis; novel phthalimide; cell lines; compound ... See more keywords
Design and synthesis of novel annulated thienopyrimidines as phosphodiesterase 5 (PDE5) inhibitors
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DOI: 10.1002/ardp.201800018
Abstract: Novel cycloalkene‐fused thienopyrimidine analogues with enhanced phosphodiesterase 5 (PDE5) inhibitory properties are presented. The structure of the reported scaffold was modulated through variation of the terminal cycloalkene ring size, as well as by varying the… read more here.
Keywords: design synthesis; synthesis novel; phosphodiesterase; phosphodiesterase pde5 ... See more keywords
Design, synthesis, and molecular docking study of benzothiazolotriazine derivatives for anticonvulsant potential
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DOI: 10.1002/ardp.201800154
Abstract: A series of newer benzothiazolotriazine derivatives (4a–k) was designed, synthesized, and characterized as anticonvulsant agents against the two classically used MES and scPTZ animal models. The synthesized derivatives were tested in vivo in both the… read more here.
Keywords: design synthesis; benzothiazolotriazine derivatives; study; animal models ... See more keywords
Design, synthesis, and antitubercular activity of 3‐amidophenols with 5‐heteroatomic substitutions
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DOI: 10.1002/ardp.201800277
Abstract: A series of novel 3‐amidophenols with 5‐heteroatomic substitutions were designed and synthesized. Several compounds showed potent antitubercular activity against Mycobacterium tuberculosis H37Ra (MIC = 0.25–5 μg/mL). Compounds 12j and 14i also displayed good inhibitory activity against M. tuberculosis… read more here.
Keywords: design synthesis; heteroatomic substitutions; activity; synthesis antitubercular ... See more keywords
Design, synthesis, biological evaluation, and molecular dynamics of novel cholinesterase inhibitors as anti‐Alzheimer's agents
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DOI: 10.1002/ardp.201800352
Abstract: A series of novel chroman‐4‐one derivatives were designed and synthesized successfully with good to excellent yield (3a–l). In addition, the obtained products were evaluated for their cholinesterase (ChE) inhibitory activities. The results show that among… read more here.
Keywords: design synthesis; cholinesterase; biological evaluation; molecular dynamics ... See more keywords