Recommendations for the design of therapeutic trials for neonatal seizures
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DOI: 10.1038/s41390-018-0242-2
Abstract: Although seizures have a higher incidence in neonates than any other age group and are associated with significant mortality and neurodevelopmental disability, treatment is largely guided by physician preference and tradition, due to a lack… read more here.
Keywords: group; trials neonatal; neonatal seizures; design therapeutic ... See more keywords
The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach
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DOI: 10.1038/s41598-017-01542-5
Abstract: The M1 family of metalloproteases represents a large number of exopeptidases that cleave single amino acid residues from the N-terminus of peptide substrates. One member of this family that has been well studied is aminopeptidase… read more here.
Keywords: rational design; therapeutic peptides; design therapeutic; peptides aminopeptidase ... See more keywords
The Neurokinins: Peptidomimetic Ligand Design and Therapeutic Applications.
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DOI: 10.2174/0929867325666180913095918
Abstract: The neurokinins are indisputably essential neurotransmitters in numerous patho- and physiological events. Being widely distributed in the central nervous system (CNS) and peripheral tissues, their discovery rapidly promoted them to drugs targets. A necessity for… read more here.
Keywords: ligand design; non peptidic; peptidomimetic ligand; neurokinins peptidomimetic ... See more keywords
Impact of Cannabinoid Receptors in the Design of Therapeutic Agents against Human Ailments.
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DOI: 10.2174/1568026623666230502120956
Abstract: The cannabinoid (CB) signalling cascade is widely located in the human body and is as-sociated with several pathophysiological processes. The endocannabinoid system comprises canna-binoid receptors CB1 and CB2, which belong to G-protein coupled receptors (GPCRs).… read more here.
Keywords: design therapeutic; agents human; cannabinoid receptors; impact cannabinoid ... See more keywords