Functional Deimmunization of Botulinum Neurotoxin Protease Domain via Computationally Driven Library Design and Ultrahigh-Throughput Screening.
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DOI: 10.1021/acssynbio.2c00426
Abstract: Botulinum neurotoxin serotype A (BoNT/A) is a widely used cosmetic agent that also has diverse therapeutic applications; however, adverse antidrug immune responses and associated loss of efficacy have been reported in clinical uses. Here, we… read more here.
Keywords: botulinum neurotoxin; throughput screening; ultrahigh throughput; design ultrahigh ... See more keywords