Designed helical peptides as functional probes for γ-secretase.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00639
Abstract: γ-Secretase is a membrane-embedded aspartyl protease complex with presenilin as the catalytic component that cleaves within the transmembrane domain (TMD) of >90 known substrates, including the amyloid precursor protein (APP) of Alzheimer's disease. Processing by… read more here.
Keywords: helical peptides; functional probes; app; probes secretase ... See more keywords
De Novo-Designed α-Helical Barrels as Receptors for Small Molecules.
Sign Up to like & getrecommendations! Published in 2018 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.8b00225
Abstract: We describe de novo-designed α-helical barrels (αHBs) that bind and discriminate between lipophilic biologically active molecules. αHBs have five or more α-helices arranged around central hydrophobic channels the diameters of which scale with oligomer state.… read more here.
Keywords: barrels receptors; receptors small; novo designed; small molecules ... See more keywords