Targeting integrin αvβ3 by a rationally designed protein for chronic liver disease treatment
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-02611-2
Abstract: Chronic Liver Diseases (CLD) are characterized by abnormal accumulation of collagen fibrils, neo-angiogenesis, and sinusoidal remodeling. Collagen deposition along with intrahepatic angiogenesis and sinusoidal remodeling alters sinusoid structure resulting in portal hypertension, liver failure, and… read more here.
Keywords: rationally designed; treatment; integrin; liver ... See more keywords
A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2021899118
Abstract: Significance Coiled-coil dimers are structural motifs which occur frequently in natural proteins. They consist of two α-helices which wind around each other to form a supercoil and can be used as versatile modules for the… read more here.
Keywords: coiled coil; designed protein; protein origami;
Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214556120
Abstract: Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, but in practice… read more here.
Keywords: cryptic transmembrane; secretion; design; designed protein ... See more keywords