Towards functional de novo designed proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in chemical biology"
DOI: 10.1016/j.cbpa.2019.06.011
Abstract: Our ability to design completely de novo proteins is improving rapidly. This is true of all three main approaches to de novo protein design, which we define as: minimal, rational and computational design. Together, these… read more here.
Keywords: designed proteins; novo designed; towards functional; functional novo ... See more keywords
From ancestral peptides to designed proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2017.11.006
Abstract: The diversity of modern proteins arose through the combinatorial shuffling and differentiation of a limited number of autonomously folding domain prototypes, but the origin of these prototypes themselves has long remained poorly understood. In recent… read more here.
Keywords: ancestral peptides; designed proteins; biology; peptides designed ... See more keywords
Designed for life: biocompatible de novo designed proteins and components
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Royal Society Interface"
DOI: 10.1098/rsif.2018.0472
Abstract: A principal goal of synthetic biology is the de novo design or redesign of biomolecular components. In addition to revealing fundamentally important information regarding natural biomolecular engineering and biochemistry, functional building blocks will ultimately be… read more here.
Keywords: designed proteins; novo designed; designed life; proteins components ... See more keywords
Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Science translational medicine"
DOI: 10.1126/scitranslmed.abn1252
Abstract: New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here we used a cell-free expression workflow to rapidly screen and optimize constructs containing… read more here.
Keywords: protection; designed proteins; multivalent designed; receptor ... See more keywords
Designed Proteins Lead Therapeutics to Cancer Cells, Spare Other Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2020-127
Abstract: Sets of modular proteins enabled targeting of cells with specific combinations of surface markers. read more here.
Keywords: designed proteins; therapeutics cancer; cancer cells; cancer ... See more keywords