Stimuli-Responsive Dynamic Metaholographic Displays with Designer Liquid Crystal Modulators.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced materials"
DOI: 10.1002/adma.202004664
Abstract: Flat optics, realized by the artificially created 2D material platform called optical metasurfaces, is currently undergoing a science-to-technology transition. However, "real-time" active operations of such flat optical devices remain yet unresolved. Here, liquid crystals (LCs)-integrated… read more here.
Keywords: designer; responsive dynamic; displays designer; stimuli responsive ... See more keywords
Engineering Mammalian Designer Cells for the Treatment of Metabolic Diseases
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Journal"
DOI: 10.1002/biot.201700160
Abstract: Synthetic biology applies engineering principles to biological systems and has significantly advanced the design of synthetic gene circuits that can reprogram cell activities to perform new functions. The ability to engineer mammalian designer cells with… read more here.
Keywords: designer; treatment metabolic; engineering; metabolic diseases ... See more keywords
Designer Benzodiazepines: Another Class of New Psychoactive Substances.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2018_154
Abstract: Benzodiazepines have been introduced as medical drugs in the 1960s. They replaced the more toxic barbiturates, which were commonly used for treatment of anxiety or sleep disorders at the time. However, benzodiazepines show a high… read more here.
Keywords: designer; another class; designer benzodiazepines; class new ... See more keywords
Generation of TALE-Based Designer Epigenome Modifiers.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7774-1_4
Abstract: Manipulation of gene expression can be facilitated by editing the genome or the epigenome. Precise genome editing is traditionally achieved by using designer nucleases which are generally exploited to eliminate a specific gene product. Upon… read more here.
Keywords: designer; tale based; designer epigenome; based designer ... See more keywords
Harnessing CRISPR-Cas systems for precision engineering of designer probiotic lactobacilli.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in biotechnology"
DOI: 10.1016/j.copbio.2018.11.009
Abstract: Our evolving understanding on the mechanisms underlying the health-promoting attributes of probiotic lactobacilli, together with an expanding genome editing toolbox have made this genus an ideal chassis for the development of living therapeutics. The rising… read more here.
Keywords: designer; engineering; crispr cas; lactobacilli ... See more keywords
Exploring the influence of designer surfactant hydrophobicity in key C C/C N bond forming reactions
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Catalysis"
DOI: 10.1016/j.mcat.2019.01.006
Abstract: Abstract Designer micellar medium was explored for the transformation of diverse anilines to the corresponding densely substituted biologically relevant skatole derivatives in an aqueous medium via 5-exo-trig cyclization reaction. The scope of the reaction was… read more here.
Keywords: designer; bond forming; hydrophobicity; exploring influence ... See more keywords
Silica-based mesoporous materials; emerging designer adsorbents for aqueous pollutants removal and water treatment
Sign Up to like & getrecommendations! Published in 2018 at "Microporous and Mesoporous Materials"
DOI: 10.1016/j.micromeso.2018.03.008
Abstract: Abstract This is a review of recent literature on pristine and specifically functionalized mesoporous silica-based materials or ‘designer silicates’ used as adsorbents for aqueous pollutants removal and water treatment. Ordered mesoporous silicates, their synthesis, surfactants… read more here.
Keywords: designer; removal water; silica based; adsorbents aqueous ... See more keywords
THE NOVEL GC-A/CGMP ACTIVATING DESIGNER M-ATRIAL NATRIURETIC PEPTIDE POTENTLY REDUCES BLOOD PRESSURE IN A GENETIC MODEL OF HYPERTENSION AND POTENTIATES THE ACTIONS OF FUROSEMIDE
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American College of Cardiology"
DOI: 10.1016/s0735-1097(19)32319-8
Abstract: MANP (ZD100) is a novel best-in-class designer pGC-A/ cGMP activator engineered at the Mayo Clinic for the treatment of resistant hypertension for which there is no FDA approved drug. MANP has recently been tested in… read more here.
Keywords: blood pressure; cgmp; designer; hypertension ... See more keywords
The challenges of solid tumor for designer CAR-T therapies: a 25-year perspective
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Gene Therapy"
DOI: 10.1038/cgt.2016.82
Abstract: Designer chimeric antigen receptor (CAR) T cells (dTc) have come to be the latest designer ‘drug’ for treatment of cancer. This technology has generated multiple apparent cures in the treatment of B-cell malignancies, but has… read more here.
Keywords: designer; designer car; solid tumor; tumor designer ... See more keywords
Type-I hyperbolic metasurfaces for highly-squeezed designer polaritons with negative group velocity
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10027-0
Abstract: Hyperbolic polaritons in van der Waals materials and metamaterial heterostructures provide unprecedented control over light-matter interaction at extreme nanoscales. Here we propose a concept of type-I hyperbolic metasurface supporting highly-squeezed magnetic designer polaritons, which act… read more here.
Keywords: designer; group velocity; highly squeezed; type hyperbolic ... See more keywords
A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
Sign Up to like & getrecommendations! Published in 2018 at "Nature Chemistry"
DOI: 10.1038/s41557-018-0082-z
Abstract: Creating designer enzymes with the ability to catalyse abiological transformations is a formidable challenge. Efforts toward this goal typically consider only canonical amino acids in the initial design process. However, incorporating unnatural amino acids that… read more here.
Keywords: designer; hydrazone oxime; oxime formation; designer enzymes ... See more keywords