A cytokine-based designer enzyme with an abiological multinuclear metal center exhibits intrinsic and extrinsic catalysis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61909-5
Abstract: A designer enzyme consisting of an abiological molecule incorporated into a natural protein has been developed as an exceptionally chemoselective catalyst, highlighting that the internal space of proteins is highly beneficial for enhancing catalytic performance.… read more here.
Keywords: designer; designer enzyme; multinuclear metal; abiological multinuclear ... See more keywords
Abstract LB-B23: Prodrug activation by designer enzyme targeted to CD123-expressing tumors
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-17-lb-b23
Abstract: We propose the combination of tumor-targeting antibodies with a drug-activating enzyme and a prodrug, which could be expected to give synergy and enhanced therapeutic efficacy in the treatment of leukemia and other malignancies. We have… read more here.
Keywords: designer; prodrug activation; enzyme targeted; designer enzyme ... See more keywords