Generation of TALE-Based Designer Epigenome Modifiers.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7774-1_4
Abstract: Manipulation of gene expression can be facilitated by editing the genome or the epigenome. Precise genome editing is traditionally achieved by using designer nucleases which are generally exploited to eliminate a specific gene product. Upon… read more here.
Keywords: designer; tale based; designer epigenome; based designer ... See more keywords
Designer epigenome modifiers enable robust and sustained gene silencing in clinically relevant human cells
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky171
Abstract: Abstract Targeted modulation of gene expression represents a valuable approach to understand the mechanisms governing gene regulation. In a therapeutic context, it can be exploited to selectively modify the aberrant expression of a disease-causing gene… read more here.
Keywords: designer epigenome; gene expression; target; expression ... See more keywords