Designing Around Structural Alerts in Drug Discovery.
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DOI: 10.1021/acs.jmedchem.9b00917
Abstract: Cumulative research over several decades has implicated the involvement of reactive metabolites in many idiosyncratic adverse drug reactions (IADRs). Consequently, "avoidance" strategies have been inserted into drug discovery paradigms, which include the exclusion of structural… read more here.
Keywords: structural alerts; reactive metabolite; drug; designing around ... See more keywords