New designs for basket clinical trials in oncology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1372779
Abstract: ABSTRACT The established molecular heterogeneity of human cancers has had profound effects on the design of cancer therapeutics. Most cancer drugs are today targeted to molecular alterations present in cancer cells. Tumors of the same… read more here.
Keywords: designs basket; basket clinical; trials oncology; clinical trials ... See more keywords
Bayesian response-adaptive designs for basket trials.
Sign Up to like & getrecommendations! Published in 2017 at "Biometrics"
DOI: 10.1111/biom.12668
Abstract: We develop a general class of response-adaptive Bayesian designs using hierarchical models, and provide open source software to implement them. Our work is motivated by recent master protocols in oncology, where several treatments are investigated… read more here.
Keywords: designs basket; bayesian response; adaptive designs; response adaptive ... See more keywords