LAUSR

Desmin forms toxic, seeding-competent amyloid aggregates that persist in muscle fibers

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0 Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1908263116

Abstract: Significance Protein aggregation and the deposition of amyloid is a common feature in neurodegeneration, but can also be seen in degenerative muscle diseases known as myofibrillar myopathies (MFMs). Hallmark pathology in MFM patient muscle is… read more here.

Keywords: seeding competent; muscle; competent amyloid; desmin ... See more keywords