The efficacy of low‐power cumulative high‐intensity focused ultrasound treatment for recurrent desmoid tumor
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4573
Abstract: Desmoid tumors are rare neoplasms that are locally invasive. However, optimal treatment strategies for recurrent desmoid tumors remain controversial. High‐intensity focused ultrasound (HIFU) has been reported as a noninvasive modality for treating recurrent desmoid tumors.… read more here.
Keywords: focused ultrasound; recurrent desmoid; desmoid tumors; intensity focused ... See more keywords
Transarterial Chemoembolization with Doxorubicin Eluting Beads for Extra-Abdominal Desmoid Tumors: Initial Experience
Sign Up to like & getrecommendations! Published in 2022 at "CardioVascular and Interventional Radiology"
DOI: 10.1007/s00270-022-03149-4
Abstract: To evaluate the feasibility, efficacy, and safety of doxorubicin-eluting bead transarterial chemoembolization (DEB-TACE) as an alternative local treatment for extra-abdominal desmoid tumors (DTs). Eleven adult female patients (mean age = 40.1 years) with symptomatic, progressively enlarging extra-abdominal… read more here.
Keywords: transarterial chemoembolization; doxorubicin eluting; desmoid tumors; extra abdominal ... See more keywords
Multifocal occurrence of extra-abdominal desmoid type fibromatosis - A rare manifestation. A clinicopathological study of 6 sporadic cases and 1 hereditary case.
Sign Up to like & getrecommendations! Published in 2018 at "Annals of diagnostic pathology"
DOI: 10.1016/j.anndiagpath.2018.04.001
Abstract: Desmoid-type fibromatosis, also called desmoid tumor, is a locally aggressive myofibroblastic neoplasm that usually arises in deep soft tissue with significant potential for local recurrence. It displays an unpredictable clinical course. β-Catenin, the genetic key… read more here.
Keywords: desmoid tumors; multifocal desmoid; type fibromatosis; sporadic cases ... See more keywords
A Metabolomics Pilot Study on Desmoid Tumors and Novel Drug Candidates
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DOI: 10.1038/s41598-017-18921-7
Abstract: Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors that lack the ability to metastasize. There are no directed therapies or standard treatment plan, and chemotherapeutics, radiation, and surgery often have temporary effects. The… read more here.
Keywords: desmoid tumors; study; drug; t41a s45f ... See more keywords
Radiotherapy in the treatment of primary or recurrent unresectable desmoid tumors of the neck
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Investigation"
DOI: 10.1080/07357907.2019.1656731
Abstract: Abstract Purpose: Desmoid tumors are locally aggressive nonmalignant soft tissue tumors, which frequently recur after therapy. The optimal treatment is still controversial because of the lack of large research. A few studies have reported the… read more here.
Keywords: primary recurrent; desmoid tumors; unresectable desmoid; recurrent unresectable ... See more keywords
Management of unresectable and recurrent intra-abdominal desmoid tumors treated with ultrasound-guided high-intensity focused ultrasound: A retrospective single-center study
Sign Up to like & getrecommendations! Published in 2022 at "Medicine"
DOI: 10.1097/md.0000000000030201
Abstract: To assess the efficacy and safety of ultrasound (US)-guided high-intensity focused ultrasound (HIFU) ablation for treatment of unresectable and recurrent intra-abdominal desmoid tumors. From June 2014 to March 2020, 15 patients with consecutive unresectable and… read more here.
Keywords: unresectable recurrent; abdominal desmoid; desmoid tumors; intra abdominal ... See more keywords
Involvement of NY-ESO-1 and MAGE-A4 in the pathogenesis of desmoid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033908
Abstract: The involvement of New York esophageal squamous cell carcinoma-1 (NY-ESO-1) and melanoma-associated antigen A4 (MAGE-A4) in soft-tissue sarcoma pathogenesis has recently been reported; however, their involvement in desmoid tumors (DTs) remains unknown. This study aimed… read more here.
Keywords: desmoid tumors; positivity; mage; correlation ... See more keywords
Systemic Chemotherapies Retain Antitumor Activity in Desmoid Tumors Independent of Specific Mutations in CTNNB1 or APC: A Multi-institutional Retrospective Study
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DOI: 10.1158/1078-0432.ccr-21-4504
Abstract: Abstract Purpose: Determine whether specific CTNNB1 or APC mutations in patients with desmoid tumor were associated with differences in clinical responses to systemic treatments. Experimental Design: We established a multi-institutional dataset of previously treated patients… read more here.
Keywords: mutation; desmoid tumors; ctnnb1 apc; desmoid tumor ... See more keywords
Abstract 4533: Serum protein changes in patients with desmoid tumors responsive to the TBL1 inhibitor, tegavivint
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4533
Abstract: Background: A Phase 1/2 clinical trial (NCT03459469) of the small molecule tegavivint in patients with desmoid tumors (DTs), demonstrated drug safety and tolerability with evidence of clinical activity. Transducin Beta-Like Protein 1 (TBL1) is a… read more here.
Keywords: beta catenin; serum; tegavivint; desmoid tumors ... See more keywords
A cost analysis of sorafenib for desmoid tumors
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DOI: 10.1177/10781552221077927
Abstract: Introduction A recent randomized trial demonstrated that sorafenib improved progression free survival (PFS) in patients with desmoid tumors despite many patients experiencing stable disease or spontaneous regression without treatment. Utilizing these trial data, we performed… read more here.
Keywords: year; desmoid tumors; progression; analysis sorafenib ... See more keywords
Upfront surgery is not advantageous compared to more conservative treatments such as observation or medical treatment for patients with desmoid tumors
Sign Up to like & getrecommendations! Published in 2021 at "BMC Musculoskeletal Disorders"
DOI: 10.1186/s12891-020-03897-9
Abstract: Background This study compared the clinical and functional outcomes of patients initially treated with observation or medical treatment with those of patients treated with local treatment (surgery alone or surgery with adjuvant radiotherapy) to confirm… read more here.
Keywords: desmoid tumors; medical treatment; first line; observation medical ... See more keywords