Therapeutic agents for targeting desmoplasia: current status and emerging trends.
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DOI: 10.1016/j.drudis.2020.09.008
Abstract: Desmoplasia is a major barrier to chemotherapy in several cancers, particularly pancreatic ductal adenocarcinoma and breast cancer. Tumors comprise cellular and noncellular components and chemoresistant cancer stem cells (CSCs) with established signaling pathways. In this… read more here.
Keywords: targeting desmoplasia; current status; desmoplasia; agents targeting ... See more keywords
Protective Desmoplasia in Pancreatic Adenocarcinoma: High Vitamin D Receptor Expression and Collagen Content
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DOI: 10.21873/anticanres.14667
Abstract: Background/Aim: Vitamin D receptor (VDR) has been shown to suppress desmoplasia in pancreatic ductal adenocarcinoma (PDAC). Our aim was to assess the clinical effects of VDR expression and its correlation with collagen content in the… read more here.
Keywords: desmoplasia; vdr expression; collagen content; expression ... See more keywords
Emerging Kinase Therapeutic Targets in Pancreatic Ductal Adenocarcinoma and Pancreatic Cancer Desmoplasia
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DOI: 10.3390/ijms21228823
Abstract: Kinase drug discovery represents an active area of therapeutic research, with previous pharmaceutical success improving patient outcomes across a wide variety of human diseases. In pancreatic ductal adenocarcinoma (PDAC), innovative pharmaceutical strategies such as kinase… read more here.
Keywords: emerging kinase; kinase; desmoplasia; pancreatic ductal ... See more keywords