Genomic and transcriptomic characterization of desmoplastic small round cell tumors
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DOI: 10.1002/gcc.22955
Abstract: Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue tumor primarily affecting children and young adults. Most cases display a pathognomonic EWSR1‐WT1 gene fusion, presumably constituting the primary driver event. Little is,… read more here.
Keywords: desmoplastic small; round cell; tumor; small round ... See more keywords
A national analysis of patterns of care and outcomes for adults diagnosed with desmoplastic small round cell tumors in the United States
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DOI: 10.1002/jso.25426
Abstract: Because of the rarity of desmoplastic small round cell tumors (DSRCT), there is a lack of data describing patterns of care and survival for these patients. Using a national tumor registry, the current study sought… read more here.
Keywords: round cell; small round; patterns care; desmoplastic small ... See more keywords
Olaparib and temozolomide in desmoplastic small round cell tumors: a promising combination in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-020-03211-z
Abstract: Purpose Desmoplastic small round cell tumors (DSRCTs) are highly malignant and very rare soft tissue sarcomas with a high unmet need for new therapeutic options. Therefore, we examined poly(ADP-ribose) polymerase 1 (PARP1) and Schlafen-11 (SLFN11)… read more here.
Keywords: combination; olaparib tmz; combination treatment; desmoplastic small ... See more keywords
Intra-abdominal desmoplastic small round cell tumour in a 56-year-old female: Case report of a very rare presentation of an unusual tumour
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Surgery Case Reports"
DOI: 10.1016/j.ijscr.2021.01.058
Abstract: Highlights • Intra-abdominal desmoplastic small round cell tumour is a rare tumour not previously reported in a female over the age of 50.• Disparity between radiological and histological appearances should prompt further review and investigation.•… read more here.
Keywords: cell tumour; round cell; small round; abdominal desmoplastic ... See more keywords
Can we cure patients with abdominal Desmoplastic Small Round Cell Tumor? Results of a retrospective multicentric study on 100 patients.
Sign Up to like & getrecommendations! Published in 2019 at "Surgical oncology"
DOI: 10.1016/j.suronc.2019.04.002
Abstract: BACKGROUND Despite being associated with a very poor prognosis, long-term survivors across all series of Desmoplastic Small Round Cell Tumor (DSRCT) have been reported. AIM OF THE STUDY To analyze patients 'characteristics associated with a… read more here.
Keywords: desmoplastic small; small round; cell tumor; round cell ... See more keywords
Transcriptome analysis of desmoplastic small round cell tumors identifies actionable therapeutic targets: a report from the Children’s Oncology Group
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-69015-w
Abstract: To further understand the molecular pathogenesis of desmoplastic small round cell tumor (DSRCT), a fatal malignancy occurring primarily in adolescent/young adult males, we used next-generation RNA sequencing to investigate the gene expression profiles intrinsic to… read more here.
Keywords: therapeutic targets; round cell; small round; desmoplastic small ... See more keywords
Trabectedin-irinotecan, a potentially promising combination in relapsed desmoplastic small round cell tumor: report of two cases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemotherapy"
DOI: 10.1080/1120009x.2022.2067706
Abstract: Abstract Effective new drugs are urgently needed for desmoplastic small round cell tumor (DSRCT), an extremely rare and aggressive disease with a generally poor prognosis. We describe two heavily-pretreated young patients with advanced-stage DSRCT given… read more here.
Keywords: cell tumor; desmoplastic small; round cell; small round ... See more keywords
Desmoplastic small round cell tumor: from state of the art to future clinical prospects
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DOI: 10.1080/14737140.2023.2200171
Abstract: ABSTRACT Introduction Desmoplastic small round cell tumor (DSRCT) is an extremely rare and highly aggressive soft tissue sarcoma, presenting mainly in male adolescents and young adults with multiple nodules disseminated within the abdominopelvic cavity. Despite… read more here.
Keywords: cell tumor; desmoplastic small; round cell; small round ... See more keywords
OC56 Hyperthermic intraperitoneal chemotherapy for treatment of desmoplastic small round cell tumours in a child; A U.K. first
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-epa.53
Abstract: Introduction Desmoplastic small round cell tumours are rare, aggressive neoplastic tumours with a predisposition to affect the intra-abdominal cavity. Hyperthermic intraperitoneal chemotherapy (HIPEC) is a mode of delivering concentrated, heated chemotherapy directly into the abdominal… read more here.
Keywords: cell tumours; desmoplastic small; round cell; small round ... See more keywords
Solid-Pattern Desmoplastic Small Round Cell Tumor
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DOI: 10.1177/1066896916660198
Abstract: Desmoplastic small round cell tumor (DSRCT) is an aggressive small round cell sarcoma that typically occurs intra-abdominally in adolescents and young adults, and is characterized by a recurrent t(11;22)(p13;q12) translocation leading to generation of the… read more here.
Keywords: desmoplastic small; cell tumor; round cell; small round ... See more keywords
Primary Desmoplastic Small Round Cell Tumor of the Femur: Case Report and Review of a Rare Intraosseous Malignancy.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of surgical pathology"
DOI: 10.1177/10668969211046017
Abstract: Background: Desmoplastic small round cell tumors (DSRCT) are malignant neoplasms of young males arising most commonly in the abdominopelvic cavity, with a subset originating from extra-abdominal soft tissues. As either primary or metastatic lesions, they… read more here.
Keywords: round; rare intraosseous; round cell; small round ... See more keywords