Desmosomal protein degradation as an underlying cause of arrhythmogenic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2023 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.add4248
Abstract: Arrhythmogenic cardiomyopathy (ACM) is an inherited progressive cardiac disease. Many patients with ACM harbor mutations in desmosomal genes, predominantly in plakophilin-2 (PKP2). Although the genetic basis of ACM is well characterized, the underlying disease-driving mechanisms… read more here.
Keywords: arrhythmogenic cardiomyopathy; cardiomyopathy; desmosomal protein; degradation ... See more keywords
Cortical tension regulates desmosomal morphogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.946190
Abstract: Mechanical stability is a fundamental and essential property of epithelial cell sheets. It is in large part determined by cell-cell adhesion sites that are tightly integrated by the cortical cytoskeleton. An intimate crosstalk between the… read more here.
Keywords: cortical tension; tension regulates; protein turnover; desmosomal protein ... See more keywords