Modeling reduced contractility and impaired desmosome assembly due to plakophilin-2 deficiency using isogenic iPS cell-derived cardiomyocytes
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cell Reports"
DOI: 10.1016/j.stemcr.2021.12.016
Abstract: Summary Loss-of-function mutations in PKP2, which encodes plakophilin-2, cause arrhythmogenic cardiomyopathy (AC). Restoration of deficient molecules can serve as upstream therapy, thereby requiring a human model that recapitulates disease pathology and provides distinct readouts in… read more here.
Keywords: cell derived; derived cardiomyocytes; contractility; pathology ... See more keywords
EGFR inhibition leads to enhanced desmosome assembly and cardiomyocyte cohesion via ROCK activation
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DOI: 10.1172/jci.insight.163763
Abstract: Arrhythmogenic cardiomyopathy (AC) is a familial heart disease partly caused by impaired desmosome turnover. Thus, stabilization of desmosome integrity may provide new treatment options. Desmosomes, apart from cellular cohesion, provide the structural framework of a… read more here.
Keywords: desmosome assembly; inhibition; rock; cohesion ... See more keywords
E-cadherin binds to desmoglein to facilitate desmosome assembly
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DOI: 10.7554/elife.37629
Abstract: Desmosomes are adhesive junctions composed of two desmosomal cadherins: desmocollin (Dsc) and desmoglein (Dsg). Previous studies demonstrate that E-cadherin (Ecad), an adhesive protein that interacts in both trans (between opposing cells) and cis (on the… read more here.
Keywords: cadherin binds; desmosome; desmoglein facilitate; facilitate desmosome ... See more keywords