Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24âdehydrocholesterol reductase
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13095
Abstract: We have earlier reported that amiodarone, a potent and commonly used antiarrhythmic drug increases serum desmosterol, the last precursor of cholesterol, in 20 cardiac patients by an unknown mechanism. read more here.
Keywords: biosynthesis pathway; desmosterol; amiodarone disrupts; pathway causes ... See more keywords
Desmosterol Incorporation Into Ram Sperm Membrane Before Cryopreservation Improves in vitro and in vivo Fertility
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.660165
Abstract: Pregnancy rates in ewes are markedly low after cervical insemination with frozen-thawed sperm. Sensitivity of ram sperm to freeze-thawing is related to the lipid composition of the membrane, particularly to its low sterol content. Recently,… read more here.
Keywords: desmosterol; cholesterol; ram sperm; sterol ... See more keywords