Amiodarone disrupts cholesterol biosynthesis pathway and causes accumulation of circulating desmosterol by inhibiting 24‐dehydrocholesterol reductase
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Internal Medicine"
DOI: 10.1111/joim.13095
Abstract: We have earlier reported that amiodarone, a potent and commonly used antiarrhythmic drug increases serum desmosterol, the last precursor of cholesterol, in 20 cardiac patients by an unknown mechanism. read more here.
Keywords: biosynthesis pathway; desmosterol; amiodarone disrupts; pathway causes ... See more keywords
Desmosterol Incorporation Into Ram Sperm Membrane Before Cryopreservation Improves in vitro and in vivo Fertility
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.660165
Abstract: Pregnancy rates in ewes are markedly low after cervical insemination with frozen-thawed sperm. Sensitivity of ram sperm to freeze-thawing is related to the lipid composition of the membrane, particularly to its low sterol content. Recently,… read more here.
Keywords: desmosterol; cholesterol; ram sperm; sterol ... See more keywords
Desmosterol as a Novel Biomarker Linking Cholesterol Metabolism, Liver Inflammation, and Cardiovascular Risk in Metabolic Dysfunction-Associated Steatotic Liver Disease.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of atherosclerosis and thrombosis"
DOI: 10.5551/jat.ed297
Abstract: into disease activity. In this issue of J Atheroscler Thromb, Omatsu and colleagues report that serum desmosterol, a cholesterol synthesis intermediate converted by Δ 24-dehydrocholesterol reductase (DHCR24), correlates with histological inflammation grade in biopsy-proven MASLD… read more here.
Keywords: inflammation grade; disease; desmosterol; inflammation ... See more keywords