Epithelial desquamation observed in a phase I study of an oral cathepsin C inhibitor (GSK2793660)
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DOI: 10.1111/bcp.13398
Abstract: AIMS Cathepsin C (CTSC) is necessary for the activation of several serine proteases including neutrophil elastase (NE), cathepsin G and proteinase 3. GSK2793660 is an oral, irreversible inhibitor of CTSC that is hypothesized to provide… read more here.
Keywords: inhibitor; ctsc; cathepsin; phase study ... See more keywords
First case of Rubinstein–Taybi syndrome with desquamation associated with a novel mutation in the bromodomain of the CREBBP gene
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13871
Abstract: Rubinstein–Taybi syndrome (RSTS) is a rare congenital disorder, mainly characterized by postnatal growth retardation, intellectual disability, and facial and limb abnormalities. Although not considered as characteristic manifestations, numerous cutaneous anomalies have also been reported in… read more here.
Keywords: bromodomain crebbp; novel mutation; rubinstein taybi; mutation bromodomain ... See more keywords
The Preventive Effects of Boron-Based Gel on Radiation Dermatitis in Patients Being Treated for Breast Cancer: A Phase III Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Sign Up to like & getrecommendations! Published in 2022 at "Oncology Research and Treatment"
DOI: 10.1159/000520363
Abstract: Introduction: Radiation dermatitis (RD) is a side effect of radiation therapy (RT) which is experienced by over 90% of patients being treated for breast cancer. The current clinical trial was conducted to measure the preventative… read more here.
Keywords: boron based; placebo; group; breast cancer ... See more keywords
Use of Chamomile Infusion to Mitigate Radiotherapy-Induced Dry Desquamation in Head and Neck Cancer Patients
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DOI: 10.1177/15347354221105491
Abstract: Purpose: To evaluate the effect of using a compress with Chamomilla recutita infusion in the regression of dry desquamation and in the prevention of moist desquamation in head and neck cancer patients undergoing radiotherapy. Methods:… read more here.
Keywords: regression; radiotherapy; infusion; desquamation ... See more keywords
The Molting Man: Anasarca-Induced Full-Body Desquamation.
Sign Up to like & getrecommendations! Published in 2022 at "Cutis"
DOI: 10.12788/cutis.0493
Abstract: Blisters and subsequent desquamation of the skin in the presence of acute edema is a well-known clinical phenomenon. In this case report, we describe a new variant that we have termed anasarca-induced desquamation in a… read more here.
Keywords: man; desquamation; induced desquamation; acute edema ... See more keywords
Human Tissue Kallikreins-Related Peptidases Are Targets for the Treatment of Skin Desquamation Diseases
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2021.777619
Abstract: Human tissue Kallikrein-related peptidases (hKLKs) are serine proteases distributed in several tissues that are involved in several biological processes. In skin, many are responsible for skin desquamation in the Stratum Corneum (SC) of the epidermis,… read more here.
Keywords: skin desquamation; skin diseases; desquamation; related peptidases ... See more keywords
The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions
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DOI: 10.3390/ijms23137486
Abstract: We evaluated the presence of tight junction (TJ) remnants in the stratum corneum (SC) of in vitro reconstructed human epidermis and human skin explants subjected or not to an aggressive topical treatment with beta-lipohydroxy salicylic… read more here.
Keywords: fate epidermal; stratum corneum; tight junctions; epidermal tight ... See more keywords