Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Cell"
DOI: 10.1016/j.molcel.2021.07.013
Abstract: Summary The Wnt/β-catenin pathway is a highly conserved, frequently mutated developmental and cancer pathway. Its output is defined mainly by β-catenin’s phosphorylation- and ubiquitylation-dependent proteasomal degradation, initiated by the multi-protein β-catenin destruction complex. The precise… read more here.
Keywords: catenin; destruction complex; phosphorylation ubiquitylation;
HUWE1 loss promotes stemness and drug resistance in CRC with dysregulated β-catenin destruction complex
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02731-2
Abstract: Cancer stem cells (CSCs) are a key driver of tumor initiation, progression, and drug resistance in colorectal cancer (CRC). The Wnt/β-catenin signaling pathway, which is hyperactivated in nearly all CRC cases, plays a crucial role… read more here.
Keywords: huwe1; catenin; destruction complex; drug resistance ... See more keywords
APC controls Wnt-induced β-catenin destruction complex recruitment in human colonocytes
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-59899-z
Abstract: Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis Coli ( APC ). APC is an essential component of a… read more here.
Keywords: destruction complex; destruction; wnt induced; catenin destruction ... See more keywords
Molecular regulation and pharmacological targeting of the β‐catenin destruction complex
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13922
Abstract: The β‐catenin destruction complex is a dynamic cytosolic multiprotein assembly that provides a key node in Wnt signalling regulation. The core components of the destruction complex comprise the scaffold proteins axin and adenomatous polyposis coli… read more here.
Keywords: molecular regulation; destruction; catenin destruction; destruction complex ... See more keywords
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1011677
Abstract: WNT/β-catenin signaling is mediated by the transcriptional coactivator β-catenin (CTNNB1). CTNNB1 abundance is regulated by phosphorylation and proteasomal degradation, promoted by a destruction complex composed of the scaffold proteins APC and AXIN1 or AXIN2, and… read more here.
Keywords: abundance; huwe1; degradation; destruction complex ... See more keywords
SIRT4-Catalyzed Deacetylation of Axin1 Modulates the Wnt/β-Catenin Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.872444
Abstract: Axin1 is a fundamental scaffolding protein of the destruction complex in the canonical Wnt signaling pathway, which plays a critical role in various biological processes. However, how Axin1 is regulated in the activation of the… read more here.
Keywords: destruction complex; signaling pathway; deacetylation; wnt ... See more keywords
Expression profile of components of the β-catenin destruction complex in oral dysplasia and oral cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Medicina oral, patologia oral y cirugia bucal"
DOI: 10.4317/medoral.24528
Abstract: BACKGROUND Oral cancer represents the sixth most common cancer in the world and is associated with 40-50% survival at 5 years. Within oral malignancies, oral squamous cell carcinoma (OSCC) is commonly preceded by potentially malignant… read more here.
Keywords: oral dysplasia; catenin destruction; components catenin; destruction complex ... See more keywords