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   Articles with "desumoylation" as a keyword



SENP1-mediated deSUMOylation of YBX1 promotes colorectal cancer development through the SENP1-YBX1-AKT signaling axis

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recommendations! Published in 2025 at "Oncogene"

DOI: 10.1038/s41388-025-03302-6

Abstract: Aberrant SUMOylation is associated with the progression of colorectal cancer (CRC). The SUMO-specific protease 1 (SENP1)-induced deSUMOylation of different target substrates plays specific roles in CRC. In this study, we dissected the SENP1-interacting protein complex… read more here.

Keywords: senp1 mediated; senp1 ybx1; desumoylation; protein ... See more keywords

SENP5 promotes endometrial cancer cell growth by regulating β-catenin deSUMOylation to enhance GPX4-resistance to ferroptosis

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recommendations! Published in 2025 at "European Journal of Medical Research"

DOI: 10.1186/s40001-025-02662-9

Abstract: Endometrial cancer (EC) is a significant and serious gynecological cancer, constituting a considerable risk to women's health. The desumoylation of SUMO specific peptidase 5 (SENP5) is intricately linked with various cancers. Nonetheless, the function of… read more here.

Keywords: catenin; senp5; desumoylation; endometrial cancer ... See more keywords

High-fat Diet-induced deSUMOylation of E4BP4 Promotes Lipid Droplet Biogenesis and Liver Steatosis in Mice.

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recommendations! Published in 2022 at "Diabetes"

DOI: 10.2337/db22-0332

Abstract: Dysregulated lipid droplet accumulation has been identified as one of the main contributors to liver steatosis during nonalcoholic fatty liver disease (NAFLD). However, the underlying molecular mechanisms for excessive lipid droplet formation in the liver… read more here.

Keywords: e4bp4; desumoylation; droplet; lipid droplet ... See more keywords

SENP1 promotes triple-negative breast cancer invasion and metastasis via enhancing CSN5 transcription mediated by GATA1 deSUMOylation

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recommendations! Published in 2022 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.60594

Abstract: TNBC is characterized by high incidence of visceral metastasis and lacks effective clinical targets. This study aims to delineate the molecular mechanisms of SENP1 in TNBC invasion and metastasis. By using IHC to test the… read more here.

Keywords: expression; tnbc; metastasis; senp1 ... See more keywords