The influence of polymeric excipients on desupersaturation profiles of active pharmaceutical ingredients. 1: Polyethylene glycol.
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DOI: 10.1016/j.ijpharm.2020.119317
Abstract: Polymeric excipients have proven to be beneficial in stabilizing supersaturated solutions of poorly soluble active pharmaceutical ingredients (APIs). They are therefore considered an important tool in improving oral bioavailability of such APIs. To better understand… read more here.
Keywords: crystal growth; active pharmaceutical; polymeric excipients; desupersaturation ... See more keywords
Impact of Surfactant and Surfactant-Polymer Interaction on Desupersaturation of Clotrimazole.
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DOI: 10.1016/j.xphs.2019.05.035
Abstract: The impact of surfactants on supersaturation of clotrimazole solutions was systematically evaluated. Four clinically-relevant surfactants, sodium dodecyl sulfate (SDS), vitamin E TPGS, Tween 80 and docusate sodium were studied. The induction time for nucleation and… read more here.
Keywords: interaction desupersaturation; surfactant polymer; polymer; polymer interaction ... See more keywords