Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
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DOI: 10.1016/j.bbrc.2017.03.052
Abstract: Poly(ADP-ribose) polymerases (PARPs) use nicotinamide adenine dinucleotide (NAD+) as a co-substrate to transfer ADP-ribose when it releases nicotinamide as the metabolized product. Enzymes of the PARP family play key roles in detecting and repairing DNA,… read more here.
Keywords: auto ribosylation; detecting auto; hit compounds; parp14 ... See more keywords