Liposome Enhanced Detection of Amyloid Protein Aggregates.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03597
Abstract: Thioflavin-T is used to image amyloid aggregates because of the excellent turn-on fluorescence properties, but binding affinities are low. By mounting multiple dye units on the surface of a vesicle, the binding affinity for α-synuclein… read more here.
Keywords: protein; amyloid; detection amyloid; liposome enhanced ... See more keywords
Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c02134
Abstract: RNA aptamers have garnered attention for diagnostic applications due to their ability to recognize diverse targets. Oligomers of 42-mer amyloid β-protein (Aβ42), whose accumulation is relevant to the pathology of Alzheimer’s disease (AD), are among… read more here.
Keywords: detection amyloid; rna aptamers; alzheimer disease; oligomers rna ... See more keywords
Design of functionalized β-ketoenole derivatives as efficient fluorescent dyes for detection of amyloid fibrils
Sign Up to like & getrecommendations! Published in 2018 at "New Journal of Chemistry"
DOI: 10.1039/c8nj01020j
Abstract: The self-association of proteins into insoluble filamentous aggregates – amyloid fibrils – is associated with a range of protein deposition disorders. With the aim of developing fluorescent probes sensitive to amyloid aggregates, a new series… read more here.
Keywords: ketoenole derivatives; detection amyloid; functionalized ketoenole; design functionalized ... See more keywords