Abstract 334: Detection of BRCAness by a functional biomarker
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DOI: 10.1158/1538-7445.am2018-334
Abstract: Homologous recombination (HR) is an error-free repair pathway to eliminate DNA double-strand breaks and cells with deficiency of HR repair are highly sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. Thus, targeting HR-defective cells becomes a new… read more here.
Keywords: cancer; functional biomarker; detection brcaness; brcaness functional ... See more keywords