Higher Resolution Charge Detection Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c02133
Abstract: Charge detection mass spectrometry is a single particle technique where the masses of individual ions are determined from simultaneous measurements of each ion's m/z ratio and charge. The ions pass through a conducting cylinder, and… read more here.
Keywords: resolution; mass spectrometry; charge detection; mass ... See more keywords
Stability and Dissociation of Adeno-Associated Viral Capsids by Variable Temperature-Charge Detection-Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c02378
Abstract: Adeno-associated viral (AAV) vectors have emerged as gene therapy and vaccine delivery systems. Differential scanning fluorimetry or differential scanning calorimetry is commonly used to measure the thermal stability of AAVs, but these global methods are… read more here.
Keywords: detection mass; associated viral; mass spectrometry; adeno associated ... See more keywords
Analysis of AAV-Extracted DNA by Charge Detection Mass Spectrometry Reveals Genome Truncations.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c04234
Abstract: Adeno-associated virus (AAV) is a widely used gene therapy vector. The intact packaged genome is a critical quality attribute and necessary for an effective therapeutic. In this work, charge detection mass spectrometry (CDMS) was used… read more here.
Keywords: detection mass; charge detection; mass spectrometry;
Accurate Sizing of Nanoparticles Using a High-Throughput Charge Detection Mass Spectrometer without Energy Selection.
Sign Up to like & getrecommendations! Published in 2023 at "ACS nano"
DOI: 10.1021/acsnano.3c00539
Abstract: The sizes and shapes of nanoparticles play a critical role in their chemical and material properties. Common sizing methods based on light scattering or mobility lack individual particle specificity, and microscopy-based methods often require cumbersome… read more here.
Keywords: detection mass; energy; microscopy; analysis ... See more keywords
Probing Antibody Binding to Canine Parvovirus with Charge Detection Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b08050
Abstract: There are many techniques for monitoring and measuring the interactions between proteins and ligands. Most of these techniques are ensemble methods that can provide association constants and in some cases stoichiometry. Here we use charge… read more here.
Keywords: charge detection; canine parvovirus; detection mass; mass spectrometry ... See more keywords
Charge detection mass spectrometry for the analysis of viruses and virus-like particles.
Sign Up to like & getrecommendations! Published in 2022 at "Essays in biochemistry"
DOI: 10.1042/ebc20220101
Abstract: Heterogeneity usually restricts conventional mass spectrometry to molecular weights less than around a megadalton. As a single-particle technique, charge detection mass spectrometry (CDMS) overcomes this limitation. In CDMS, the mass-to-charge (m/z) ratio and charge are… read more here.
Keywords: detection mass; mass spectrometry; charge detection; mass ... See more keywords