Structural Determinants of Constitutive Activation of Gα Proteins: Transducin as a Paradigm.
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DOI: 10.1021/acs.jctc.6b00813
Abstract: Heterotrimeric guanine nucleotide-binding proteins (Gα proteins) are intracellular nanomachines deputed to signal transduction. The switch-on process requires the release of bound GDP from a site at the interface between GTPase and helical domains. Nucleotide release… read more here.
Keywords: collective motions; nucleotide binding; determinants constitutive; constitutive activation ... See more keywords