Probing the molecular determinants of fluorinase specificity.
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DOI: 10.1039/c6cc09213f
Abstract: Molecular determinants of FlA1 fluorinase specificity were probed using 5'-chloro-5'-deoxyadenosine (5'-ClDA) analogs as substrates and FlA1 active site mutants. Modifications at F213 or A279 residues are beneficial towards these modified substrates, including 5'-chloro-5'-deoxy-2-ethynyladenosine, ClDEA (>10-fold… read more here.
Keywords: determinants fluorinase; molecular determinants; probing molecular; fluorinase specificity ... See more keywords