Validation of an LC-MS/MS method for the determination of sotorasib, a KRASG12C inhibitor, in human plasma.
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DOI: 10.4155/bio-2022-0173
Abstract: Background: Sotorasib (AMG 510) is a first-in-class KRASG12C inhibitor that received accelerated US FDA approval in 2021 for the treatment of patients with KRASG12C-mutated locally advanced or metastatic non-small-cell lung cancer. Method: An LC-MS/MS method… read more here.
Keywords: human plasma; krasg12c inhibitor; method; determination sotorasib ... See more keywords