IC/BPS‐associated alterations of M2 and M3 muscarinic acetylcholine receptor trafficking in human detrusor
Sign Up to like & getrecommendations! Published in 2019 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24087
Abstract: To explore caveolae‐ and clathrin‐mediated internalization of muscarinic M2 and M3 receptors, recycling and degradation in formalin‐fixed paraffin‐embedded detrusor sections; to study alterations possibly involved in the pathophysiology of the bladder functional disorder, interstitial cystitis/bladder… read more here.
Keywords: detrusor; alterations muscarinic; muscarinic acetylcholine; bps associated ... See more keywords
The response to letter to the Editor: “Voiding dynamics in women with urinary incontinence but without voiding symptoms”
Sign Up to like & getrecommendations! Published in 2020 at "Neurourology and Urodynamics"
DOI: 10.1002/nau.24592
Abstract: Dear Editor, We are grateful to Dr. Peter Rosier for his comments. We would like to start clarifying that we defined detrusor contraction (DET‐cont) as the increase in detrusor pressure at maximum flow rate (pdetQmax)… read more here.
Keywords: detrusor pressure; detrusor; bladder; detrusor contraction ... See more keywords
Antimuscarinic actions on bladder urothelium and lamina propria contractions are similar to those observed in detrusor smooth muscle preparations.
Sign Up to like & getrecommendations! Published in 2023 at "Neurourology and urodynamics"
DOI: 10.1002/nau.25176
Abstract: OBJECTIVES Antimuscarinic medications are the first-line treatments for overactive bladder, the most common form of bladder dysfunction. Their primary action is thought to block detrusor muscarinic receptors. It is unclear, however, if these therapeutics have… read more here.
Keywords: actions bladder; lamina propria; urothelium lamina; detrusor ... See more keywords
Involvement of TRPM4 in detrusor overactivity following spinal cord transection in mice
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DOI: 10.1007/s00210-018-1542-0
Abstract: Transient receptor potential cation channel subfamily M member 4 (TRPM4) has been shown to play a key role in detrusor contractility under physiological conditions. In this study, we investigated the potential role of TRPM4 in… read more here.
Keywords: following spinal; detrusor; trpm4; detrusor overactivity ... See more keywords
El cateterismo vesical intermitente en la insuficiencia contráctil del detrusor
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DOI: 10.1016/j.acuro.2019.11.002
Abstract: Resumen Objetivos Estudiar la influencia del cateterismo vesical intermitente (CVI) sobre la funcion del tracto urinario inferior (TUI) en pacientes con retencion urinaria (RU) por insuficiencia contractil (IC) del detrusor. Material y metodos Estudio longitudinal.… read more here.
Keywords: del; cvi; detrusor; los ... See more keywords
Intravesical Activation of the Cation Channel TRPV4 Improves Bladder Function in a Rat Model for Detrusor Underactivity.
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DOI: 10.1016/j.eururo.2018.05.020
Abstract: BACKGROUND Improvement of bladder emptying by modulating afferent nerve activity is an attractive therapeutic strategy for detrusor underactivity. Transient receptor potential vanilloid 4 (TRPV4) is a sensory ion channel in urothelial cells that contribute to… read more here.
Keywords: detrusor; trpv4; rat model; bladder function ... See more keywords
Efficacy and Safety of AbobotulinumtoxinA in Patients with Neurogenic Detrusor Overactivity Incontinence Performing Regular Clean Intermittent Catheterization: Pooled Results from Two Phase 3 Randomized Studies (CONTENT1 and CONTENT2).
Sign Up to like & getrecommendations! Published in 2022 at "European urology"
DOI: 10.1016/j.eururo.2022.03.010
Abstract: BACKGROUND For patients with neurogenic detrusor overactivity incontinence (NDOI), treatment with oral medications is often unsatisfactory. OBJECTIVE To assess the efficacy and safety of abobotulinumtoxinA (aboBoNT-A) for NDOI. DESIGN, SETTING, AND PARTICIPANTS Two randomized, double-blind… read more here.
Keywords: abobotulinumtoxina; placebo; overactivity; detrusor ... See more keywords
Single onabotulinumtoxinA 200U dose improved clinical symptoms but not urothelial dysfunction in neurogenic detrusor overactivity due to spinal cord injury.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Formosan Medical Association = Taiwan yi zhi"
DOI: 10.1016/j.jfma.2018.02.002
Abstract: OBJECTIVE To evaluate the changes in urothelial dysfunction protein expressions in bladder after onabotulinumtoxin injection and correlate that with clinical outcomes in spinal cord injury (SCI) patients. METHODS Twenty-six patients with neurogenic detrusor overactivity (NDO)… read more here.
Keywords: onabotulinumtoxina 200u; detrusor; urothelial dysfunction; treatment ... See more keywords
Long-term efficacy and safety of solifenacin in pediatric patients aged 6 months to 18 years with neurogenic detrusor overactivity: results from two phase 3 prospective open-label studies.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pediatric urology"
DOI: 10.1016/j.jpurol.2019.12.012
Abstract: INTRODUCTION The standard recommended treatment for neurogenic detrusor overactivity (NDO) is clean intermittent catheterization combined with an antimuscarinic agent. However, the adverse systemic side-effects of oxybutynin, the most widely used agent, are of concern. OBJECTIVE… read more here.
Keywords: solifenacin; detrusor; efficacy; months years ... See more keywords
Clinical and Urodynamic Results of Repeated Intradetrusor Onabotulinum Toxin A Injections in Refractory Neurogenic Detrusor Overactivity: Up to 5 Injections in a Cohort of Children With Myelodysplasia.
Sign Up to like & getrecommendations! Published in 2018 at "Urology"
DOI: 10.1016/j.urology.2017.09.005
Abstract: OBJECTIVE To determine the efficacy and safety of repeated intradetrusor onabotulinum toxin A (onaBoNT-A) injections in children with neurogenic detrusor overactivity due to myelodysplasia. MATERIALS AND METHODS The study group consisted of 19 children (4… read more here.
Keywords: detrusor; neurogenic detrusor; intradetrusor onabotulinum; repeated intradetrusor ... See more keywords
The Sustained Therapeutic Effects of Percutaneous Posterior Tibial Nerve Stimulation in the Treatment of Neurogenic Lower Urinary Tract Symptoms in patients with Parkinson's Disease: 24-Months Clinical and Urodynamic Results.
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DOI: 10.1016/j.urology.2021.01.044
Abstract: OBJECTIVE To determine the sustained therapeutic effect of percutaneous posterior tibial nerve stimulation (PTNS) treatment in Parkinson's disease (PD) patients with detrusor activity (DA) during 24 months. METHODS After 12 weeks therapy, PTNS was applied… read more here.
Keywords: sustained therapeutic; detrusor; treatment; percutaneous posterior ... See more keywords