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   Articles with "detyrosination" as a keyword



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Parthenolide Destabilizes Microtubules by Covalently Modifying Tubulin

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recommendations! Published in 2021 at "Current Biology"

DOI: 10.1016/j.cub.2020.11.055

Abstract: Detyrosination of the α-tubulin C-terminal tail is a post-translational modification (PTM) of microtubules that is key for many biological processes.1 Although detyrosination is the oldest known microtubule PTM,2-7 the carboxypeptidase responsible for this modification, VASH1/2-SVBP,… read more here.

Keywords: parthenolide; vash1 svbp; tubulin; parthenolide destabilizes ... See more keywords
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Structural insights into tubulin detyrosination by vasohibins-SVBP complex

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recommendations! Published in 2019 at "Cell Discovery"

DOI: 10.1038/s41421-019-0133-7

Abstract: Dear Editor, Microtubules are major elements of the cytoskeleton in eukaryotic cells, essential to a wide variety of cellular functions, including cell shape control, cell division, morphogenesis, motility, and motor protein-based intracellular transport. Microtubules are… read more here.

Keywords: svbp complex; vasohibins svbp; detyrosination; tubulin detyrosination ... See more keywords
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Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis

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recommendations! Published in 2019 at "Cell Research"

DOI: 10.1038/s41422-019-0187-y

Abstract: Abstractα-Tubulin detyrosination, largely catalyzed by vasohibins, is involved in many microtubule (MT)-related cellular events. In this study, we identified a core heterodimeric complex of human small vasohibin-binding protein (SVBP) and vasohibin 1 (VASH1) (hereafter denoted… read more here.

Keywords: spindle function; mitosis; vasohibins mediated; detyrosination ... See more keywords
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Microtubule detyrosination drives symmetry breaking to polarize cells for directed cell migration.

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recommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.2139/ssrn.4156165

Abstract: To initiate directed movement, cells must become polarized, establishing a protrusive leading edge and a contractile trailing edge. This symmetry-breaking process involves reorganization of cytoskeleton and asymmetric distribution of regulatory molecules. However, what triggers and… read more here.

Keywords: cell; detyrosination; symmetry breaking; cell migration ... See more keywords