LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "deubiquitinase" as a keyword



Photo by markusspiske from unsplash

Modulation of Schwann cell homeostasis by the BAP1 deubiquitinase

Sign Up to like & get
recommendations! Published in 2023 at "Glia"

DOI: 10.1002/glia.24351

Abstract: Schwann cell programming during myelination involves transcriptional networks that activate gene expression but also repress genes that are active in neural crest/embryonic differentiation of Schwann cells. We previously found that a Schwann cell‐specific deletion of… read more here.

Keywords: bap1; schwann; injury; schwann cell ... See more keywords
Photo by diana_pole from unsplash

The deubiquitinase STAMBP modulates cytokine secretion through the NLRP3 inflammasome.

Sign Up to like & get
recommendations! Published in 2020 at "Cellular signalling"

DOI: 10.1016/j.cellsig.2020.109859

Abstract: The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a multimeric, cytoplasmic, protein complex that regulates maturation and secretion of interleukin (IL)-1β, a potent pro-inflammatory cytokine. Critical to host defense against pathogens, IL-1β… read more here.

Keywords: deubiquitinase; secretion; deubiquitinase stambp; stambp modulates ... See more keywords
Photo from wikipedia

The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13

Sign Up to like & get
recommendations! Published in 2020 at "Cellular and Molecular Immunology"

DOI: 10.1038/s41423-020-0362-6

Abstract: Dendritic cells (DCs) are indispensable for defense against pathogens but may also contribute to immunopathology. Activation of DCs upon the sensing of pathogens by Toll-like receptors (TLRs) is largely mediated by pattern recognition receptor/nuclear factor-κB… read more here.

Keywords: deubiquitinase; production; dcs; infection ... See more keywords
Photo from wikipedia

Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity

Sign Up to like & get
recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep43180

Abstract: The overexpression of Mdm2 has been linked to the loss of p53 tumour suppressor activity in several human cancers. Here, we present results suggesting that ubiquitin-specific peptidase 48 (USP48), a deubiquitinase that has been linked… read more here.

Keywords: deubiquitinase; specific peptidase; deubiquitinase activity; mdm2 ... See more keywords
Photo from wikipedia

Proteasomal deubiquitinase UCH37 inhibits degradation of &bgr;-catenin and promotes cell proliferation and motility

Sign Up to like & get
recommendations! Published in 2019 at "Acta Biochimica et Biophysica Sinica"

DOI: 10.1093/abbs/gmy176

Abstract: The ubiquitin-proteasome system degrades most cellular proteins in eukaryotes. UCH37, also known as UCH-L5, is a deubiquitinase binding to Rpn13, a receptor for ubiquitinated substrates in the 26 S proteasome. But, it remains unclear how… read more here.

Keywords: degradation; deubiquitinase; cell proliferation; catenin ... See more keywords
Photo by drew_hays from unsplash

Deubiquitinase fine-tunes Notch signaling

Sign Up to like & get
recommendations! Published in 2019 at "Science"

DOI: 10.1126/science.364.6436.141-q

Abstract: Signal Transduction The branching of blood vessels is controlled in part by signaling through Notch receptor proteins. When NOTCH1 binds its ligand DLL4, the intracellular domain (NICD1) is cleaved from the receptor and works with… read more here.

Keywords: science; deubiquitinase; tunes notch; notch signaling ... See more keywords

SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy

Sign Up to like & get
recommendations! Published in 2018 at "PLoS Pathogens"

DOI: 10.1371/journal.ppat.1007071

Abstract: HIV-1 Tat is a key regulator of viral transcription, however little is known about the mechanisms that control its turnover in T cells. Here we use a novel proteomics technique, called DiffPOP, to identify the… read more here.

Keywords: deubiquitinase; destruction; brcc36; hiv tat ... See more keywords
Photo by erik_karits from unsplash

Characterisation of the OTU domain deubiquitinase complement of Toxoplasma gondii

Sign Up to like & get
recommendations! Published in 2023 at "Life Science Alliance"

DOI: 10.26508/lsa.202201710

Abstract: The OTU deubiquitinase family is expanded in Toxoplasma parasites, and members show preferences for Lys6-, Lys11-, Lys48-, and Lys63-linked ubiquitin chains, and additional specificity for NEDD8. AlphaFold-guided structural analysis reveals cryptic ubiquitin-binding domains with functional… read more here.

Keywords: otu; apicomplexan parasites; characterisation; toxoplasma ... See more keywords
Photo by lucasmarcomini from unsplash

OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase

Sign Up to like & get
recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22041936

Abstract: Aurora kinases are serine/threonine kinases required for cell proliferation and are overexpressed in many human cancers. Targeting Aurora kinases has been a therapeutic strategy in cancer treatment. Here, we attempted to identify a deubiquitinase (DUB)… read more here.

Keywords: deubiquitinase; kinase; otud6a aurora; aurora kinase ... See more keywords
Photo from wikipedia

Deubiquitinase OTUD7B is a potential prognostic biomarker in diffuse large B-cell lymphoma

Sign Up to like & get
recommendations! Published in 2022 at "Journal of Cancer"

DOI: 10.7150/jca.65835

Abstract: OTUD7B is a deubiquitinase and has been reported as a prognostic factor in various solid tumors. However, its prognostic value in lymphoma patients remains unclear. We detected OTUD7B expression levels in 160 diffuse large B-cell… read more here.

Keywords: cell; cell lymphoma; large cell; diffuse large ... See more keywords