The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway
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DOI: 10.1371/journal.ppat.1007435
Abstract: Stimulator of interferon genes (STING) is critical for cytosolic DNA-triggered innate immunity. STING is modified by several types of polyubiquitin chains. Here, we report that the deubiquitinase CYLD sustains STING signaling by stabilizing the STING… read more here.
Keywords: cyld; deubiquitinase cyld; signaling pathway; polyubiquitin chains ... See more keywords