The deubiquitinase Otub1 controls the activation of CD8 T cells and NK cells by regulating IL-15-mediated priming
Sign Up to like & getrecommendations! Published in 2019 at "Nature immunology"
DOI: 10.1038/s41590-019-0405-2
Abstract: CD8+ T cells and natural killer (NK) cells are central cellular components of immune responses against pathogens and cancer, which rely on interleukin (IL)-15 for homeostasis. Here we show that IL-15 also mediates homeostatic priming… read more here.
Keywords: cd8; deubiquitinase otub1; cd8 cells; activation ... See more keywords
The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031536
Abstract: Dysregulated energy metabolism is a major contributor to a multitude of pathologies, including obesity and diabetes. Understanding the regulation of metabolic homeostasis is of utmost importance for the identification of therapeutic targets for the treatment… read more here.
Keywords: energy metabolism; energy; otub1 key; regulator ... See more keywords