Discovery of a small‐molecule inhibitor targeting the ovarian tumor domain of a novel Tamdy orthonairoviruse associated with human febrile illness
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28089
Abstract: Tick‐borne orthonairoviruses have been characterized as a global health threat to humans and animals. Tacheng Tick virus 1 (TcTV‐1) from this family was provided as evidence that is associated with the febrile illness syndrome. Here,… read more here.
Keywords: domain; deubiquitinating activity; ovarian tumor; febrile illness ... See more keywords
Myricetin exerts its antiviral activity against infectious bronchitis virus by inhibiting the deubiquitinating activity of papain-like protease.
Sign Up to like & getrecommendations! Published in 2021 at "Poultry science"
DOI: 10.1016/j.psj.2021.101626
Abstract: Infectious bronchitis virus (IBV) is a causative agent that causes severe economic losses in the poultry industry worldwide. Papain-like protease (PLpro) is a nonstructural protein encoded by IBV. It has deubiquitinating enzyme activity, which can… read more here.
Keywords: infectious bronchitis; inhibiting deubiquitinating; deubiquitinating activity; myricetin ... See more keywords