Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradation
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11812
Abstract: Although a variety of molecular targets have been identified, hepatocellular carcinoma (HCC) remains among the leading causes of death. As functions of they deubiquitinating enzyme Josephin domain containing 2 (JOSD2) in cancers are still poorly… read more here.
Keywords: hepatocellular carcinoma; hcc; progression; deubiquitinating enzyme ... See more keywords
The deubiquitinating enzyme USP20 regulates the stability of the MCL1 protein.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.01.019
Abstract: Chemoresistance is a major obstacle faced by oesophageal cancer patients and is synonymous with a poor prognosis. MCL1 is a pivotal member of the anti-apoptotic Bcl-2 protein family, which has been found to play an… read more here.
Keywords: enzyme usp20; usp20 regulates; mcl1; deubiquitinating enzyme ... See more keywords
Role of the deubiquitinating enzyme UCH-L1 in mitochondrial function
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2023.1149954
Abstract: COPYRIGHT © 2023 Bouron, Aubry, Loreth, Fauvarque and Meyer-Schwesinger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is… read more here.
Keywords: enzyme uch; uch mitochondrial; role deubiquitinating; mitochondrial function ... See more keywords
The deubiquitinating enzyme MINDY2 promotes pancreatic cancer proliferation and metastasis by stabilizing ACTN4 expression and activating the PI3K/AKT/mTOR signaling pathway
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1169833
Abstract: The pathogenic mechanisms of pancreatic cancer (PC) are still not fully understood. Ubiquitination modifications have a crucial role in tumorigenesis and progression. Yet, the role of MINDY2, a member of the motif interacting with Ub-containing… read more here.
Keywords: pi3k akt; mindy2; pancreatic cancer; expression ... See more keywords
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012527
Abstract: Proteins related to the ubiquitin-proteasome system play an important role during the differentiation and ciliogenesis of photoreceptor cells. Mutations in several genes involved in ubiquitination and proteostasis have been identified as causative of inherited retinal… read more here.
Keywords: enzyme usp48; deubiquitinating enzyme; usp48 interacts; interacts retinal ... See more keywords