Cellular functions regulated by deubiquitinating enzymes in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2021 at "Ageing Research Reviews"
DOI: 10.1016/j.arr.2021.101367
Abstract: Neurodegenerative diseases are one of the most common diseases in mankind. Although there are reports of several candidates that cause neurodegenerative diseases, the exact mechanism of pathogenesis is poorly understood. The ubiquitin-proteasome system (UPS) is… read more here.
Keywords: functions regulated; disease; neurodegenerative diseases; cellular functions ... See more keywords
Possible roles of the transcription factor Nrf1 (NFE2L1) in neural homeostasis by regulating the gene expression of deubiquitinating enzymes.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.01.038
Abstract: The transcription factor Nrf1 (NFE2L1) maintains protein homeostasis (proteostasis) by regulating the gene expression of proteasome subunits in response to proteasome inhibition. The deletion of the Nrf1 gene in neural stem/progenitor cells causes severe neurodegeneration… read more here.
Keywords: expression deubiquitinating; gene expression; transcription factor; expression ... See more keywords
Regulation of T helper cell differentiation by E3 ubiquitin ligases and deubiquitinating enzymes.
Sign Up to like & getrecommendations! Published in 2017 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2016.11.013
Abstract: CD4 T cells are essential components of adaptive immunity and play a critical role in anti-pathogenic or anti-tumor responses as well as autoimmune and allergic diseases. Naive CD4 T cells differentiate into distinct subsets of… read more here.
Keywords: cell differentiation; ligases deubiquitinating; ubiquitin ligases; differentiation ... See more keywords
High-throughput screening of functional deubiquitinating enzymes in autophagy
Sign Up to like & getrecommendations! Published in 2020 at "Autophagy"
DOI: 10.1080/15548627.2020.1761652
Abstract: ABSTRACT Macroautophagy/autophagy, a eukaryotic homeostatic process that sequesters cytoplasmic constituents for lysosomal degradation, is orchestrated by a number of autophagy-related (ATG) proteins tightly controlled by post-translational modifications. However, the involvement of reversible ubiquitination in the… read more here.
Keywords: throughput screening; autophagy; atg proteins; autophagy high ... See more keywords
Deubiquitinating enzymes UBP12 and UBP13 stabilize the brassinosteroid receptor BRI1
Sign Up to like & getrecommendations! Published in 2022 at "EMBO reports"
DOI: 10.15252/embr.202153354
Abstract: Protein ubiquitination is a dynamic and reversible post‐translational modification that controls diverse cellular processes in eukaryotes. Ubiquitin‐dependent internalization, recycling, and degradation are important mechanisms that regulate the activity and the abundance of plasma membrane (PM)‐localized… read more here.
Keywords: bri1; enzymes ubp12; deubiquitinating enzymes; ubp12 ubp13 ... See more keywords
Regulation of Protein Degradation and Homeostasis by the Cytokine- Inducible Deubiquitinating Enzymes
Sign Up to like & getrecommendations! Published in 2018 at "Journal for ImmunoTherapy of Cancer"
DOI: 10.17352/2455-8591.000019
Abstract: Ubiquitin-proteasome system (UPS) is the major signaling pathway responsible for regulating protein turnover in cells. Deubiquitinating enzymes (DUBs) have an important role in this signaling pathway by eliminating ubiquitins from substrates and inhibiting proteasomal degradation… read more here.
Keywords: degradation; degradation homeostasis; regulation protein; protein degradation ... See more keywords
Deubiquitinating Enzymes in Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.00535
Abstract: Mitochondrial dysfunction and neurodegeneration have been directly correlated in many neurodegenerative disorders. Parkinson’s disease (PD) in particular has been extensively studied in this context because of its well-characterized association with mitophagy, a selective type of… read more here.
Keywords: deubiquitinating enzymes; enzymes parkinson; disease; parkinson disease ... See more keywords
Cellular Functions of Deubiquitinating Enzymes in Ovarian Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14040886
Abstract: In ovarian cancer patients, the 5-year survival rate is 90% for stages I and II, but only 30% for stages III and IV. Unfortunately, as 75% of the patients are diagnosed at stages III and… read more here.
Keywords: enzymes ovarian; ovarian adenocarcinoma; ovarian cancer; deubiquitinating enzymes ... See more keywords
Targeting Deubiquitinating Enzymes (DUBs) That Regulate Mitophagy via Direct or Indirect Interaction with Parkin
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012105
Abstract: The quality control of mitochondria is critical for the survival of cells, and defects in the pathways required for this quality control can lead to severe disease. A key quality control mechanism in cells is… read more here.
Keywords: targeting deubiquitinating; quality control; enzymes dubs; regulate mitophagy ... See more keywords
Advances in deubiquitinating enzymes in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer"
DOI: 10.7150/jca.56532
Abstract: The process of ubiquitination and deubiquitination is widely present in the human body's protein reactions and plays versatile roles in multiple diseases. Deubiquitinating enzymes (DUBs) are significant regulators of this process, which cleave the ubiquitin… read more here.
Keywords: lung adenocarcinoma; deubiquitinating enzymes; enzymes lung; advances deubiquitinating ... See more keywords