USP12 positively regulates M‐MDSC function to inhibit antitumour immunity through deubiquitinating and stabilizing p65
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13552
Abstract: The relative abundance of myeloid‐derived suppressor cells (MDSCs) compared to cytotoxic T cells determines the outcomes of diseases and the efficacy of immunotherapy. Ubiquitin‐specific peptidase 12 (USP12), a member of the USP family of deubiquitinases,… read more here.
Keywords: function; mdscs; stabilizing p65; positively regulates ... See more keywords
OTUD5 promotes the growth of hepatocellular carcinoma by deubiquitinating and stabilizing SLC38A1
Sign Up to like & getrecommendations! Published in 2024 at "Biology Direct"
DOI: 10.1186/s13062-024-00475-0
Abstract: Background Deubiquitinating enzymes (DUBs) cleave ubiquitin on substrate molecules to maintain protein stability. DUBs reportedly participate in the tumorigenesis and tumour progression of hepatocellular carcinoma (HCC). OTU deubiquitinase 5 (OTUD5), a DUB family member, has… read more here.
Keywords: hcc; stabilizing slc38a1; deubiquitinating stabilizing; hcc cell ... See more keywords
USP26 regulates TGF‐β signalling by deubiquitinating and stabilizing SMAD7; not applicable in glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "EMBO reports"
DOI: 10.15252/embr.201847030
Abstract: Comment on "USP26 regulates TGF-β signaling by deubiquitinating and stabilizing SMAD7" by Kit Leng Lui et al. read more here.
Keywords: tgf signalling; regulates tgf; stabilizing smad7; deubiquitinating stabilizing ... See more keywords