CXCR4 up‐regulation mediated by USP1 deubiquitination promotes the tumorigenesis and immune escape in esophageal squamous‐cell carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.70004
Abstract: CXC chemokine receptor 4 (CXCR4) and ubiquitin specific protease 1 (USP1) have been reported to involve in the tumorigenesis of esophageal squamous‐cell carcinoma (ESCC). Here, we investigated whether USP1 induced CXCR4 deubiquitination in regulating ESCC… read more here.
Keywords: deubiquitination; cxcr4; immune escape; cell ... See more keywords
The ubiquitination-deubiquitination cycle on the ribosomal protein eS7A is crucial for efficient translation
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DOI: 10.1016/j.isci.2021.102145
Abstract: Summary Ubiquitination is a major post-translational modification of ribosomal proteins. The role of ubiquitination in the regulation of ribosome functions is still being elucidated. However, the importance of ribosome deubiquitination remains unclear. Here, we show… read more here.
Keywords: ubiquitination deubiquitination; cycle; efficient translation; ubiquitination ... See more keywords
An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.07.023
Abstract: Poly-ubiquitin chains direct protein substrates to the 26S proteasome, where they are removed by the deubiquitinase Rpn11 during ATP-dependent substrate degradation. Rapid deubiquitination is required for efficient degradation but must be restricted to committed substrates that… read more here.
Keywords: switch; rpn11; 26s proteasome; aaa motor ... See more keywords
Ubiquitin-specific peptidase 30-mediated deubiquitination of forkhead box O3 promotes the progression of subarachnoid hemorrhage by regulating cGAS/STING pathway
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DOI: 10.1097/wnr.0000000000002192
Abstract: Background Subarachnoid hemorrhage (SAH) is a cerebrovascular disease with a very high disability and mortality rate, which brings a huge economic burden to society. It is reported that inhibition of forkhead box O3 (FOXO3) can… read more here.
Keywords: specific peptidase; deubiquitination; pyroptosis; forkhead box ... See more keywords
Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia
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DOI: 10.1126/sciadv.abq8437
Abstract: Dysregulation of kinase signaling pathways favors tumor cell survival and therapy resistance in cancer. Here, we reveal a posttranslational regulation of kinase signaling and nuclear receptor activity via deubiquitination in T cell acute lymphoblastic leukemia… read more here.
Keywords: deubiquitination; kinase; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Abstract 4363062: BRCC3 inhibition of EndoMT via deubiquitination of Smad7: Implication in Atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Circulation"
DOI: 10.1161/circ.152.suppl_3.4363062
Abstract: Background: Endothelial-to-mesenchymal transition (EndoMT), driven by the TGF-β/Smad2/3 signaling, contributes to endothelial dysfunction and atherosclerosis. BRCC3 is a K63-dependent deubiquitinase know to downregulate Smad pathways, but its role in EndoMT and atherosclerosis remains unclear. Objective:… read more here.
Keywords: endomt via; deubiquitination; implication atherosclerosis; atherosclerosis ... See more keywords
Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance
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DOI: 10.1186/s12943-024-01996-y
Abstract: CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has not… read more here.
Keywords: cdc6 otud6a; deubiquitination; otud6a; otud6a cdc6 ... See more keywords
SPICE1 promotes osteosarcoma growth by enhancing the deubiquitination of FASN mediated by USP10
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-025-06248-1
Abstract: Osteosarcoma (OS) is recognized as a prevalent primary bone malignancy, particularly affecting adolescents during their growth spurts. Despite its clinical significance, the underlying biological characteristics and associated prognostic factors remain incompletely understood. The identification of… read more here.
Keywords: spice1 promotes; deubiquitination; usp10 fasn; fasn ... See more keywords
Unlocking hepatocellular carcinoma aggression: STAMBPL1-mediated TRAF2 deubiquitination activates WNT/PI3K/NF-kb signaling pathway
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DOI: 10.1186/s13062-024-00460-7
Abstract: STAM Binding Protein Like 1 (STAMBPL1), functions as a deubiquitinase (DUB) and plays a significant role in various types of cancers. However, its effect as a DUB participating in the HCC tumorigenesis and progression still… read more here.
Keywords: deubiquitination; stambpl1; pi3k signaling; wnt pi3k ... See more keywords
Characterization of the deubiquitination activity and substrate specificity of the chicken ubiquitin-specific protease 1/USP associated factor 1 complex
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DOI: 10.1371/journal.pone.0186535
Abstract: Deubiquitinases (DUBs) are essential regulators of intracellular processes involving ubiquitin (Ub) modification. The human DUB ubiquitin-specific protease 1 (hUSP1) interacts with human USP-associated factor 1 (hUAF1), and helps to regulate processes such as DNA damage… read more here.
Keywords: chusp1; ubiquitin specific; chuaf1; deubiquitination activity ... See more keywords
USP16 Regulates the Stability and Function of LDL receptor by Deubiquitination.
Sign Up to like & getrecommendations! Published in 2020 at "International heart journal"
DOI: 10.1536/ihj.20-043
Abstract: Low-density lipoprotein (LDL) particles are known to be atherogenic agents in coronary artery diseases. They adjust to other electronegative forms and can be the subject for the enhancement of inflammatory events in vessel subendothelial spaces.… read more here.
Keywords: ldl receptor; regulates stability; usp16 regulates; receptor ... See more keywords