The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Aging Cell"
DOI: 10.1111/acel.13051
Abstract: The pathology of spinocerebellar ataxia type 3, also known as Machado‐Joseph disease, is triggered by aggregation of toxic ataxin‐3 (ATXN3) variants containing expanded polyglutamine repeats. The physiological role of this deubiquitylase, however, remains largely unclear.… read more here.
Keywords: joseph disease; machado joseph; deubiquitylase; lc3c gabarap ... See more keywords
A versatile new tool derived from a bacterial deubiquitylase to detect and purify ubiquitylated substrates and their interacting proteins
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001501
Abstract: Protein ubiquitylation is an important posttranslational modification affecting a wide range of cellular processes. Due to the low abundance of ubiquitylated species in biological samples, considerable effort has been spent on methods to purify and… read more here.
Keywords: tool; versatile new; detect; ubiquitylated proteins ... See more keywords