Synthesis of Deuterated Heterocycles with Me2NCD(OMe)2 and Evaluation of the Products for Metabolism by Aldehyde Oxidase.
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DOI: 10.1021/acsmedchemlett.1c00634
Abstract: The metabolic oxidation of drug-like small molecules by aldehyde oxidase (AO) has commonly been mitigated through the incorporation of deuterium at the oxidation site. We report that dimethylformamide dimethyl acetal and related compounds undergo rapid… read more here.
Keywords: metabolism; aldehyde oxidase; deuterated heterocycles; me2ncd ome ... See more keywords