The rate of lactate production from glucose in hearts is not altered by per-deuteration of glucose.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of magnetic resonance"
DOI: 10.1016/j.jmr.2017.09.007
Abstract: This study was designed to determine whether perdeuterated glucose experiences a kinetic isotope effect (KIE) as glucose passes through glycolysis and is further oxidized in the tricarboxylic acid (TCA) cycle. Metabolism of deuterated glucose was… read more here.
Keywords: glucose; deuteration; lactate; rate ... See more keywords
Quantitative High-Field NMR- and Mass Spectrometry-Based Fatty Acid Sequencing Reveals Internal Structure in Ru-Catalyzed Deuteration of Docosahexaenoic Acid.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c00923
Abstract: Ru-based catalysis results in highly unsaturated fatty acid (HUFA) ethyl esters (EE) deuterated to various extents. The products carry 2H (D) mainly at their bis-allylic positions, where they are resistant to autoxidation compared to natural… read more here.
Keywords: deuteration; allylic positions; bis allylic; high field ... See more keywords
Twelfth-Position Deuteration of Nevirapine Reduces 12-Hydroxy-Nevirapine Formation and Nevirapine-Induced Hepatocyte Death
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.9b01990
Abstract: Cytochrome P450-dependent metabolism of the anti-HIV drug nevirapine (NVP) to 12-hydroxy-NVP (12-OHNVP) has been implicated in NVP toxicities. We investigated the impact of twelfth-position trideuteration (12-D3NVP) on the hepatic metabolism of and response to NVP.… read more here.
Keywords: nevirapine; twelfth position; deuteration; formation ... See more keywords
Nickel-Catalyzed Asymmetric Transfer Hydrogenation and α-Selective Deuteration of N-Sulfonyl Imines with Alcohols: Access to α-Deuterated Chiral Amines.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02921
Abstract: A nickel-catalyzed enantioselective transfer hydrogenation and deuteration of N-sulfonyl imines was developed. Excellent α-selectivity and high deuterium content were achieved by using inexpensive 2-propanol-d8 as a deuterium source. As a highlight, no deuteration of β-C-H… read more here.
Keywords: deuteration sulfonyl; sulfonyl imines; deuteration; transfer hydrogenation ... See more keywords
Copper-Catalyzed Formal Transfer Hydrogenation/Deuteration of Aryl Alkynes.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03632
Abstract: A copper-catalyzed reduction of alkynes to alkanes and deuterated alkanes is described under transfer hydrogenation and transfer deuteration conditions. Commercially available alcohols and silanes are used interchangeably with their deuterated analogues as the hydrogen or… read more here.
Keywords: deuteration; transfer hydrogenation; aryl alkynes; transfer ... See more keywords
Palladium-Catalyzed Remote meta-C-H Bond Deuteration of Arenes Using a Pyridine Template.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01784
Abstract: Palladium-catalyzed meta-selective C-H deuteration of a series of substrates, including phenylacetic acids, hydrocinnamic acid, benzylphosphonate, benzylsulfonate, and benzyl and phenyl ethyl alcohol ester, is developed by using a pyridine-based directing template. The template is installed… read more here.
Keywords: using pyridine; deuteration; template; catalyzed remote ... See more keywords
Lifetime Enhancement and Degradation Study of Blue OLEDs Using Deuterated Materials.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c22882
Abstract: Significant lifetime enhancement, up to an eight-fold increase in T90, has been demonstrated in blue organic light-emitting diode (OLED) devices through the deuteration of host and hole transport materials. We observed a progressive increase in… read more here.
Keywords: transport materials; deuteration; using deuterated; enhancement degradation ... See more keywords
Site-Specific and Degree-Controlled Alkyl Deuteration via Cu-Catalyzed Redox-Neutral Deacylation.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04382
Abstract: Deuterated organic compounds have become increasingly important in many areas; however, it remains challenging to install deuterium site-selectively to unactivated aliphatic positions with control of the degree of deuteration. Here, we report a Cu-catalyzed degree-controlled… read more here.
Keywords: deuteration; specific degree; redox neutral; site specific ... See more keywords
A mild, general, and metal-free method for site-specific deuteration induced by visible light using D2O as the source of deuterium atoms
Sign Up to like & getrecommendations! Published in 2020 at "Green Chemistry"
DOI: 10.1039/c9gc04096j
Abstract: A radical deuteration procedure using D2O as the source of deuterium atoms is strongly preferred in terms of mildness, sustainability, and cost. Herein, we disclose a radical approach for site-specific, highly efficient and metal-free deuteration… read more here.
Keywords: site specific; deuteration; deuterium atoms; using d2o ... See more keywords
C-H deuteration of organic compounds and potential drug candidates.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d0cs01496f
Abstract: C-H deuteration has been intricately developed to satisfy the urgent need for site-selectively deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope effects of reactions but recently its significance in pharmaceutical chemistry… read more here.
Keywords: compounds potential; deuteration; potential drug; organic compounds ... See more keywords
Silver-catalyzed regioselective deuteration of (hetero)arenes and α-deuteration of 2-alkyl azaarenes
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/d0ra02358b
Abstract: A simple silver-catalyzed regioselective deuteration of (hetero)arenes and α-deuteration of 2-alkyl azaarenes has been described. This strategy provides an efficient and practical avenue to access various deuterated electron-rich arenes, azaarenes and α-deuterated 2-alkyl azaarenes with… read more here.
Keywords: silver catalyzed; deuteration hetero; alkyl azaarenes; deuteration ... See more keywords