Continuous-Flow Hydrogenation and Reductive Deuteration of Nitriles: a Simple Access to α,α-Dideutero Amines.
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DOI: 10.1002/cplu.201900526
Abstract: A simple and efficient continuous flow methodology has been developed for hydrogenation and reductive deuteration of nitriles to yield primary amines and also valuable α,α-dideutero analogues. Raney nickel proved to be a useful catalyst for… read more here.
Keywords: deuteration nitriles; hydrogenation reductive; reductive deuteration; continuous flow ... See more keywords
Ene Reactivity of an Fe═NR Bond Enables the Catalytic α-Deuteration of Nitriles and Alkynes.
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DOI: 10.1021/jacs.2c07462
Abstract: Herein, we report the reactions of an Fe(II) imido complex [Ph2B(tBuIm)2Fe═NDipp]- (1) with internal alkynes and isobutyronitrile, affording the Fe amido allenyl complexes [Ph2B(tBuIm)2Fe(NHDipp)((R1)C═C═C(R2)(H))]- (R1 = Et or nPr; R2 = Me or Et, 2-5)… read more here.
Keywords: ph2b tbuim; bond; reactivity; nitriles alkynes ... See more keywords