Base-Mediated Deuteration of Organic Molecules: A Mechanistic Insight.
Sign Up to like & getrecommendations! Published in 2018 at "ACS omega"
DOI: 10.1021/acsomega.8b01329
Abstract: A base-promoted, step-economical, and cost-effective strategy for introducing heavy isotopes into the organic molecules has been developed. The schemes involve the selective deuteration of various electronically distinct molecules that are formed because of deuterioamination, deuteriothiolation,… read more here.
Keywords: base mediated; deuteration organic; mediated deuteration; base ... See more keywords
C-H deuteration of organic compounds and potential drug candidates.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Society reviews"
DOI: 10.1039/d0cs01496f
Abstract: C-H deuteration has been intricately developed to satisfy the urgent need for site-selectively deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope effects of reactions but recently its significance in pharmaceutical chemistry… read more here.
Keywords: compounds potential; deuteration; potential drug; organic compounds ... See more keywords