Deuteration Strategy-Inspired Design of Novel Diarylpyrimidine Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Improved Efficacy, Selectivity, and Druggability.
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DOI: 10.1021/acs.jmedchem.5c00202
Abstract: Deuteration strategy holds significant importance in the field of drug development. In this study, the deuteration strategy was applied to incorporate deuterated methyl groups at the metabolic sites where methyl groups were originally present, with… read more here.
Keywords: deuteration strategy; druggability; non nucleoside; deuteration ... See more keywords