Develop a Compact RNA Base Editor by Fusing ADAR with Engineered EcCas6e.
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DOI: 10.1002/advs.202206813
Abstract: Catalytically inactive CRISPR-Cas13 (dCas13)-based base editors can achieve the conversion of adenine-to-inosine (A-to-I) or cytidine-to-uridine (C-to-U) at the RNA level, however, the large size of dCas13 protein limits its in vivo applications. Here, a compact… read more here.
Keywords: compact rna; base editor; rna base; develop compact ... See more keywords