Utilizing combinatorial engineering to develop Tie2 targeting antagonistic angiopoetin-2 ligands as candidates for anti-angiogenesis therapy
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DOI: 10.18632/oncotarget.16827
Abstract: In many human cancers, the receptor tyrosine kinase (RTK) Tie2 plays important roles in mediating proliferation, survival, migration and angiogenesis. Thus, molecules that could potently inhibit activation of the Tie2 receptor would have a significant… read more here.
Keywords: utilizing combinatorial; engineering; develop tie2; angiogenesis ... See more keywords